Arizona Cardinals WR Early Doucet (concussion) was ruled out Friday after missing practice for the third consecutive day.
Rookie Michael Floyd is expected to start in his place against the Detroit Lions with Andre Roberts getting a majority of his snaps in the slot.
Safety James Sanders (calf) is also expected to sit out Sunday after being slapped with a doubtful tag.
Additionally, the Cardinals have four players with a 50-50 chance of playing Sunday after the team assigned them probable tags: DE Calais Campbell (calf), TE Rob Housler (knee/ankle), DE Ronald Talley (ankle) and DT Dan Williams (hamstring).
Housler's injury is particularly concerning after he missed practice Friday only one day after being upgraded to full participation status. Kent Somers of the Arizona Republic speculated that he aggravated one of his injuries which could be enough of a setback to sit out.
Beyond that, the Cardinals have six players listed as probable: DT Nick Eason (ankle), LS Mike Leach (back/shoulder), S Kerry Rhodes (abdomen), WR Andre Roberts (ankle), CB Greg Toler (hamstring) and RB Beanie Wells (knee).