The Arizona Cardinals opened up as 3½-point favorites over the Buffalo Bills for Sunday's game at University of Pheonix Stadium. Money is already coming in on the Cards, and the line has since moved to 4½.
The total opened at 44, but has since moved to either 42½ or 43, depending on the source.
The Cards will be looking to bounce back from their loss to the St. Louis Rams last Thursday and move to 5-1 on the season. Arizona is tied with the San Francisco 49ers for first place in a hotly contested NFC West. The Rams and Seattle Seahawks are both just one game behind at 3-2.
The Bills will be coming off an embarrassing loss at the hands of the 49ers. Buffalo gave up 621 yards of total offense in a 45-3 blowout defeat. The Bills have now lost two straight games after beginning the season 2-1.