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NFL lines and odds Week 8: 49ers vs. Cardinals

The Arizona Cardinals return home this week, but opened as 4-point underdogs to the 49ers.

Brace Hemmelgarn-US PRESSWIRE

The Arizona Cardinals opened as a 4-point underdog this week, despite hosting the game at University of Phoenix Stadium.

The Cardinals have been impressive at home, winning eight of their last nine home games, but are an underdog to the NFC West leading San Francisco 49ers. The 49ers are 5-2 on the season and have won seven of their last 10 games against the Cardinals. They have also covered the spread in the majority of those games as, according to Odds, San Francisco is 7-2-1 against the spread in their last 10 games against Arizona.

While Arizona opened as a 4-point underdog, that number has increased to 7-points in some places. The total opened at 37, which may signal a low scoring game. The total has gone under in four of the last six games between Arizona and San Francisco. This season, the total has gone under in six of Arizona's seven games and four of San Francisco's.

While the Cardinals beat the 49ers at home last season, it was their first win in the last six meetings.