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Week 6 NFL odds: Bills vs. Cardinals

Odds for the Cardinals matchup wit the Bills this Sunday.

Greg M. Cooper-US PRESSWIRE - Presswire

After suffering their first loss of the season last week against the St. Louis Rams, the Arizona Cardinals are looking to bounce back against the Buffalo Bills from the University of Phoenix Stadium this Sunday.

Oddsmakers saw the Cardinals as 3-point favorites to start the week, though the line has moved to 4.5 for most online betting sites, while Bovada has pushed it as far as five points. As for the over/under, that started the week at 44 but has since moved to around 43-43.5.

Arizona is 1-4 against the spread in their last five meetings with the Bills, while the total has gone under in four of their last five games. Buffalo is 1-9 in their last 10 games on the road, and are 4-10 against the spread over their last 14 games. Arizona is 5-0 in their last five games at home.

Kickoff is set for 1:05 p.m. PT with coverage on the CBS Network.