The Arizona Cardinals will begin their 2012 NFL regular-season schedule when they host the Seattle Seahawks at 1:25 p.m. Sunday. The two teams wrapped up the 2011 season in the same location, with the Cards taking the game in overtime.
Football-starved fans won't have to wait until Sunday to get their fix, as the Dallas Cowboys travel to the Super Bowl Champion New York Giants on Wednesday night. The Giants swept the series from the Cowboys in 2011 on their way to securing the NFC East title with a 9-7 record.
Sunday's action is highlighted by the San Francisco 49ers making a visit to the Green Bay Packers in a battle of division champions from a year ago. Sunday night will be capped off by star quarterback Peyton Manning's debut with the Denver Broncos as they take on the Pittsburgh Steelers.
Head to SI.com for a complete NFL Week 1 Schedule.