The Arizona Cardinals will look to rebound from their first loss of the season last week as the Buffalo Bills come to town in Week 6. Both teams are battling a bunch of injuries, especially on the offensive line. There is plenty of talent at the playmaker positions for Arizona and Buffalo, but this one may be a low scoring, grind it out affair.

The Cardinals are without running backs Beanie Wells and Ryan Williams, which will likely prompt head coach Ken Whisenhunt to experiment with a couple options out of the backfield. It is also likely Kevin Kolb throws the ball a bit more than he is accustomed to. Larry Fitzgerald and Andre Roberts could be in for big games against a poor Buffalo secondary.

The Bills have a wealth of running backs with Fred Jackson and C.J. Spiller, but three of their starting five offensive lineman are out with various injuries. Quarterback Ryan Fitzpatick can throw for plenty of yards, although turnovers have been an issue in recent weeks.

Game Time/Date: Sunday, Oct. 9; 4:05 p.m. ET

Location: University of Phoenix Stadium, Glendale, Arizona

TV Schedule: CBS

Regional TV Coverage Map: The506.com

Odds: The Cardinals opened as 3 1/2 point favorites.