The Arizona Cardinals are eight-point underdogs to the NFC West-leading San Francisco 49ers, and even though they can pull into a tie in the division with a win, it seems that too much is working against the home team.

The Cardinals (4-3) are in a three-game losing streak. They still have a strong defense, but their offense is nowhere close to where it could be. Part of that is injury-related. But against a team with a strong defense like the 49ers, Arizona could be in for a long night on its home field.

The Oddsshark..com trends tell another story. San Francisco is 8-2 in its last 10 October games; the Cards are 1-9.

There remain major protection issues for the Cardinals, and those will be tested by ferocious 49ers pass rush. Arizona's defense should keep this from being a blowout, but the 49ers are poised to show that they are still the top dog in a pretty good division.

The Cardinals don't have a good history on Monday night, having lost eight of the last nine MNF games they have played. It's bound to go their way one Monday. Just not likely this one.